Interaction of large scale organic ions of pharmaceutical interest.
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Interaction of large scale organic ions of pharmaceutical interest.

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Published by University of Aston in Birmingham, Department of Pharmacy in Birmingham .
Written in English


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Edition Notes

SeriesPh.D. thesis
ID Numbers
Open LibraryOL20910065M

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Interaction of large scale organic ions of pharmaceutical interest Author: Mukhayer, Gasim I. ISNI: Awarding Body: University of Aston in Birmingham Current Institution: Aston University Date of Award: Availability of Full Text: Author: Gasim I. Mukhayer. Scale-Up and Postapproval Changes (SUPAC) are the superior interest of the Food and Drug Administration (FDA) (Diaz et al., ; Khatri et al., ). Associations among the FDA, the. In this study, spontaneous dispersion and large-scale deformation of a bulk LM were disclosed to be induced by ferric ions. It was found that the bulk LM immersed in the FeCl 3 solution can spontaneously disperse into a large amount of droplets. In addition, the dispersed LM droplets could move and deform by increasing the concentration of the Cited by: 4. The scale may have formed via the interaction of Mg ions with Na 2−x (WO 4) 1−x (OH) x-type species, which are frequently found to present in the concentrated basic sodium tungstate solution. Scale also contained MgWO 4 as a minor phase. Another scale, which is .

  Large organic ion interactions have implications for drug dosage form design, especially with regard to drug compatibility, stability and biological availability. Charged ions here refer to chemicals often used as, for example, antimicrobial preservatives (e.g. benzalkonium chloride), taste-makers (e.g. saccharin sodium), solubilizers (e.g. sodium dodecylsulphate) and colours (e.g. . Hydrophobic interaction, typical for large unhydrated (hydrophobic) univ alent ions, was proposed as a mechanism of ion-pair formation in aqueous solution by Diamond [30]. The.   The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and.   In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals, and the methods that have been used for their production. Moreover, cocrystals of pharmaceutical interest, their in vitro properties, and any available data on their in vivo performance will be discussed.

Despite their promising development, the application of cocrystals in the pharmaceutical industry is still limited due to the lack of a suitable production method on a large scale, as well as the uncertainty created by their classification by FDA as “intermediate medicinal products”, regarding the coformer as .   Porous organic solids with large voids and high framework stability have been produced14,15, and investigations into the range of accessible pore functionalities have been initiated7,11,12,16,   Polymer-Based ATPS Pharmaceutical Industry Applications. After fermentation, separation of API from cells and cell debris is often achieved via centrifugation, however centrifugation becomes increasingly complex on scale up from bench (50 mL) to industrial scale (1, L) (Majekodunmi, ).Thus, there exists a need to explore advanced scalable separation processes .   Large scale E. coli fermentation systems for plasmid DNA production have been developed and the success of this process will be dependent on the interactions between the host organism, the recombinant plasmid vector, its copy number, the gene size and the growth environment.